Overview

  • Product nameRo 25-6981 maleate salt
  • Description
    NR2B antagonist
  • Alternative names
    • Ro25-6981 maleate salt
  • Biological description

    Potent, highly selective, activity-dependent blocker of NMDA receptors that contain the NR2B subunit (IC50 values are 0.009 and 52 μM at NR1C/NR2B and NR1C/NR2A, respectively). Displays no significant activity at kainate/AMPA receptors, Na+ and Ca2+ channels at concentrations showing maximal protection in neurotoxicity tests. Neuroprotective actions in vivo and in vitro.

    Also available in simple stock solutions (ab146695) - add 1 ml of water to get an exact, ready-to-use concentration.

  • Purity> 98%

Properties

    Ro 25-6981 maleate salt images

    • Averaged time courses of NMDA receptor-isolated synaptic field potentials in dorsal lateral bed nucleus of the stria terminalis following 60 minutes of Ro 25-6981 (0.2, 2.0, or 10 μM; ab120290) in slices from naive adult male C57BL/6J mice.

    References for Ro 25-6981 maleate salt (ab120290)

    This product has been referenced in:
    • Chazot PL The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. Curr Med Chem 11:389-96 (2004). Read more (PubMed: 14965239) »
    • Lynch DR  et al. Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. Eur J Pharmacol 416:185-95 (2001). Read more (PubMed: 11290368) »
    • Fischer G  et al. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 283:1285-92 (1997). Read more (PubMed: 9400004) »

    See all 6 Publications for this product

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