Overview

  • Product name
    Ro 25-6981 maleate salt (mM/ml)
  • Description
    NR2B antagonist. 1 ml water soluble pack.
  • Biological description
    Potent, highly selective, activity-dependent blocker of NMDA receptors that contain the NR2B subunit (IC50 values are 0.009 and 52 μM at NR1C/NR2B and NR1C/NR2A, respectively). Displays no significant activity at kainate/AMPA receptors, Na+ and Ca2+ channels at concentrations showing maximal protection in neurotoxicity tests. Neuroprotective actions in vivo and in vitro.

    Soluble in 1 ml water to give specified mM/ml concentration. Find out more.
  • Purity
    > 98%

Properties

  • Chemical name
    [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
  • Molecular weight
    455.55
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H29NO2.C4H4O4
  • CAS Number
    169274-78-6
  • PubChem identifier
    53250677
  • Storage instructions
    Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in 1 ml water to give specified mM/ml concentration
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    O=C(O)/C=CC(=O)O.Oc1ccc(cc1)[C@H](O)[C@@H](C)CN2CCC(CC2)Cc3ccccc3
  • Source

    Synthetic

  • Research areas

References

ab146695 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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