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Product name
Ro 31-8220 mesylate (Bisindolylmaleimide IX)
Description
Protein kinase inhibitor
Alternative names
- Bisindolylmaleimide IX
Biological description
Widely used as a cell permeable, reversible, competitive protein kinase C inhibitor. Also potently inhibits wide range of kinases inlcuding RSK1, RSK2, PRK2, PKCα, PKD1, MSK1, GSK3β, CDK2-cyclin A and PIM3, as well as PKCα.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione methanesulfonate
Molecular Weight
553.65
Chemical structure
Molecular formula
C25H23N5O2S.CH3SO3H
CAS Number
125314-64-9
Solubility
Soluble in DMSO to 100 mM and in ethanol to 5 mM
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Protein Kinase C >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> General >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Ro 31-8220 mesylate (Bisindolylmaleimide IX) (ab120374)
This product has been referenced in:
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
- Davis PD et al. Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity. J Med Chem 35:994-1001 (1992).Read more (PubMed: 1552513) »
See all 3 publications for this product
Publishing research using ab120374? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"