Overview

  • Product name
    Ro 67-4853
  • Description
    PAM for mGlu1
  • Biological description
    Potent, selective positive allosteric modulator for mGlu1 (pEC50 = 7.16 for rat mGlu1a receptors). Increases basal mGluR1-induced cAMP accumulation and potentiates glutamate-induced cAMP accumulation. Selectively enhanced responses to DHPG in vivo (EC50= 95 nM in CA3 neurons).
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Salt TE  et al. Potentiation of sensory responses in ventrobasal thalamus in vivo via selective modulation of mGlu1 receptors with a positive allosteric modulator. Neuropharmacology 62:1695-9 (2012). Read more (PubMed: 22178704) »
  • Sheffler DJ & Conn PJ Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells. Neuropharmacology 55:419-27 (2008). Read more (PubMed: 18625258) »
  • Hemstapat K  et al. A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol Pharmacol 70:616-26 (2006). Read more (PubMed: 16645124) »
  • Knoflach F  et al. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc Natl Acad Sci U S A 98:13402-7 (2001). Read more (PubMed: 11606768) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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