Overview

  • Product name
    Rofecoxib
  • Description
    Selective COX-2 inhibitor. NSAID.
  • Biological description
    Selective COX-2 inhibitor. NSAID. Inhibits prostaglandin biosynthesis. Shows anti-inflammatory, analgesic, and antipyretic effects in vivo. Orally active. Blood-brain barrier permeable.

Properties

  • Chemical name
    3-(4-Methylsulfonylphenyl)-4-phenyl-2H-furan-5-one
  • Molecular weight
    314.36
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H14O4S
  • CAS Number
    162011-90-7
  • PubChem identifier
    5090
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Gruen M  et al. Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat. J Neurosci Methods 232:118-24 (2014). Read more (PubMed: 24861422) »
  • Li X  et al. Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). FASEB J 27:4987-97 (2013). Read more (PubMed: 24005906) »
  • Miyajima A  et al. Disruption of elastic lamellae in aorta and dysfunction of vaso-regulation by rofecoxib in rats. J Toxicol Sci 38:719-29 (2013). Read more (PubMed: 24025789) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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