Biological descriptionSelective D2-like receptor agonist. Displays high affinity for D2 and D3 but little for D1 receptors (Ki values are 7.2, 22 and >7000 nM, respectively). Shows anti-Parkinsonian activity.
Chemical name4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Ropinirole hydrochloride (ab120575)
This product has been referenced in:
McCall RB et al. Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease. J Pharmacol Exp Ther314:1248-56 (2005).
Read more (PubMed: 15980060) »
Millan MJ et al. S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole. J Pharmacol Exp Ther309:921-35 (2004).
Read more (PubMed: 14978195) »
Eden RJ et al. Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav38:147-54 (1991).
Read more (PubMed: 1673248) »