Reversible sodium ion influx inhibitor. Long-acting amide local anaesthetic agent.
Reversible sodium ion influx inhibitor. Long-acting amide local anesthetic agent. Blocks impulse conduction in nerve fibers. Less lipophilic than bupivacaine (ab142490, ab143182) so shows more sensory nerve selectivity. Shows anesthetic effects in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Uemura Y et al. Effects of various antiepileptics used to alleviate neuropathic pain on compound action potential in frog sciatic nerves: comparison with those of local anesthetics. Biomed Res Int2014:540238 (2014).
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Mantha VR et al. Nanoanesthesia: a novel, intravenous approach to ankle block in the rat by magnet-directed concentration of ropivacaine-associated nanoparticles. Anesth Analg118:1355-62 (2014).
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Zhang L et al. Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons. Eur J Pharmacol734:132-6 (2014).
Read more (PubMed: 24726558) »