Anti-ROR alpha antibody (ab70061)


  • Product nameAnti-ROR alpha antibody
    See all ROR alpha primary antibodies
  • Description
    Rabbit polyclonal to ROR alpha
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to N terminal amino acids 31-70 of Human ROR alpha

  • Positive control
    • Human breast carcinoma tissue, extracts from HeLa and COS-7 cells.



Our Abpromise guarantee covers the use of ab70061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 63 kDa (predicted molecular weight: 63 kDa).
ELISA 1/40000.
IHC-P 1/50 - 1/100.


  • FunctionOrphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.
  • Tissue specificityWidely expressed in a number of tissues.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Post-translational
    Phosphorylation by PKC in neurons inhibits transcriptional activity. Phosphorylated on Thr-216 by ERK2 in vitro.
    Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIASy but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1.
    Ubiquitinated. Ubiquitination is required for efficient transcriptional activity and is prevented by Hairless.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • fhl2a antibody
    • NR1F1 antibody
    • Nuclear receptor ROR-alpha antibody
    • Nuclear receptor RZR-alpha antibody
    • Nuclear receptor subfamily 1 group F member 1 antibody
    • RAR-related orphan receptor A antibody
    • Retinoid-related orphan receptor-alpha antibody
    • Rora antibody
    • RORA_HUMAN antibody
    • RZR-ALPHA antibody
    • RZRA antibody
    see all

Anti-ROR alpha antibody images

  • All lanes : Anti-ROR alpha antibody (ab70061) at 1/500 dilution

    Lane 1 : extract from HeLa cells
    Lane 2 : extract from COS-7 cells
    Lane 3 : extract from COS-7 cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 63 kDa
    Observed band size : 63 kDa
  • Human breast carcinoma tissue with ab70061 at 1/50 dilution, with and without the immunising peptide.

References for Anti-ROR alpha antibody (ab70061)

ab70061 has not yet been referenced specifically in any publications.

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This antibody can react with isoform 2.
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