Anti-ROR alpha + beta + gamma antibody [H3925] (ab41942)

Overview

  • Product name
    Anti-ROR alpha + beta + gamma antibody [H3925]
  • Description
    Mouse monoclonal [H3925] to ROR alpha + beta + gamma
  • Specificity
    This antibody specifically recognizes ROR alpha, beta
  • Tested applications
    Suitable for: WB, ELISA, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 136-236 of Human ROR alpha + beta + gamma

  • Positive control
    • Rat kidney collecting tubule and rat cerebrum nerve cells.
  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by July 2018 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause. 

Properties

Applications

Our Abpromise guarantee covers the use of ab41942 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 52 kDa.
ELISA Use a concentration of 0.2 µg/ml.
IP Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.

Target

  • Relevance
    ROR alpha, beta and gamma are members of the NR1 subfamily of nuclear hormone receptors. They can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. ROR alpha binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. ROR beta is required for normal postnatal development of rod and cone photoreceptor cells.
  • Cellular localization
    Nuclear
  • Database links
  • Alternative names
    • NR1F1 antibody
    • RAR-related orphan receptor alpha antibody
    • RAR-related orphan receptor beta antibody
    • RAR-related orphan receptor gamma antibody
    • ROR1 antibody
    • ROR2 antibody
    • ROR3 antibody
    • RORA antibody
    • RORB antibody
    • RORC antibody
    • RZRA antibody
    see all

Images

  • Ab41942 at 10 µg/ml staining rat cerebrum nerve cells.
  • Ab41942 at 10 µg/ml staining rat kidney collecting tubules.

References

This product has been referenced in:
  • Ma A  et al. Anti-inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells. Mol Med Rep 15:3615-3622 (2017). Read more (PubMed: 28440447) »

See 1 Publication for this product

Customer reviews and Q&As

Thank you for your enquiry. I am sorry that we do not have any experimental data for these 3 (ab41941, ab13114, ab13116) products that show reactivity with RORgamma T. Human RORgamma T is not clearly mentioned in NCBI database of Entrez. I only...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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