Overview

  • Product name
  • Description
    Goat polyclonal to ROR1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    GNKSQKPYKIDSKQA

    , corresponding to C terminal amino acids 903-917 of Human ROR1.

  • Positive control
    • Human Liver and Prostate tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab111174 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Tyrosine-protein kinase receptor whose role is not yet clear.
  • Tissue specificity
    Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
    Contains 1 FZ (frizzled) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 kringle domain.
    Contains 1 protein kinase domain.
  • Developmental stage
    Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dJ537F10.1 antibody
    • Inactive tyrosine protein kinase transmembrane receptor ROR1 antibody
    • MGC99659 antibody
    • Neurotrophic tyrosine kinase antibody
    • Neurotrophic tyrosine kinase receptor related 1 antibody
    • Neurotrophic tyrosine kinase, receptor related 1 antibody
    • NTRKR1 antibody
    • OTTHUMP00000010573 antibody
    • OTTHUMP00000010574 antibody
    • OTTMUSP00000008344 antibody
    • Receptor tyrosine kinase like orphan receptor 1 antibody
    • receptor-related 1 antibody
    • RGD1559469 antibody
    • ROR 1 antibody
    • ROR1 antibody
    • ROR1_HUMAN antibody
    • RP11 24J23.1 antibody
    • Tyrosine kinase like orphan receptor 1 antibody
    • Tyrosine protein kinase transmembrane receptor ROR1 antibody
    • Tyrosine-protein kinase transmembrane receptor ROR1 antibody
    see all

Images

  • ab111174, at 3 µg/ml, staining ROR1 in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.
  • ab111174, at 3 µg/ml, staining ROR1 in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry, followed by biotinylated secondary antibody, alkaline phosphatase streptavidin and chromogen.

References

This product has been referenced in:
  • Yamaguchi T  et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun 7:10060 (2016). Read more (PubMed: 26725982) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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