Overview

  • Product name
    Anti-RP1 antibody
  • Description
    Rabbit polyclonal to RP1
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 1254-1400 of Human RP1.

  • Positive control
    • Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher order stacking of outer segment disks along the photoreceptor axoneme.
  • Tissue specificity
    Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas.
  • Involvement in disease
    Defects in RP1 are the cause of retinitis pigmentosa type 1 (RP1) [MIM:180100]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Sequence similarities
    Contains 2 doublecortin domains.
  • Domain
    The doublecortin domains, which mediate interaction with microtubules, are required for regulation of microtubule polymerization and function in photoreceptor differentiation.
  • Cellular localization
    Cytoplasm > cytoskeleton > cilium axoneme. Cell projection > cilium > photoreceptor outer segment. Specifically localized in the connecting cilia of rod and cone photoreceptors.
  • Information by UniProt
  • Database links
  • Alternative names
    • DCDC4A antibody
    • ORP1 antibody
    • Oxygen-regulated protein 1 antibody
    • Retinitis pigmentosa 1 protein antibody
    • Retinitis pigmentosa RP1 protein antibody
    • RP1 antibody
    • RP1_HUMAN antibody
    see all

Images

  • ab122781, at 1/1000 dilution, staining RP1 in Paraffin Embedded Human kidney tissue by Immunohistochemistry.

References

ab122781 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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