Overview

  • Product name
    Anti-RP105 antibody [RP/14]
    See all RP105 primary antibodies
  • Description
    Rat monoclonal [RP/14] to RP105
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • General notes


    Cross linking of CD180 with clone RP/14 has been reported to induce resistance against irradiation induced apoptosis, B-cell proliferation and up-regulation of a co-stimulatory molecule B7.2.

Properties

Applications

Our Abpromise guarantee covers the use of ab33758 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 10µl for 106 cells.

Use 10µl to label 106 cells in 100µl.





ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • Function
    May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
  • Tissue specificity
    Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
  • Sequence similarities
    Belongs to the Toll-like receptor family.
    Contains 19 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD180 antibody
    • CD180 antigen antibody
    • CD180_HUMAN antibody
    • F630107B15 antibody
    • LY64 antibody
    • Ly78 antibody
    • Lymphocyte antigen 64 antibody
    • lymphocyte antigen 64 radioprotective 105kDa antibody
    • lymphocyte antigen-64, radioprotective, 105kDa antibody
    • MGC126233 antibody
    • MGC126234 antibody
    • Radioprotective 105 kDa protein antibody
    • RP105 antibody
    see all

References

This product has been referenced in:
  • Nagai Y  et al. Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood 99:1699-705 (2002). Read more (PubMed: 11861286) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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