• Product name
  • Description
    Rabbit polyclonal to RPC62
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Gorilla
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 200-250 of Human RPC62

  • Positive control
    • Whole cell lysate from HeLa cells.



Our Abpromise guarantee covers the use of ab111995 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
    • Sequence similarities
      Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • DNA directed III 62 kDa polypeptide antibody
      • DNA-directed RNA polymerase III subunit C antibody
      • DNA-directed RNA polymerase III subunit rpc3 antibody
      • POLR3C antibody
      • Polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody
      • RNA polymerase C subunit 3 antibody
      • RNA polymerase III 62 kDa subunit antibody
      • RNA polymerase III C62 subunit antibody
      • RNA polymerase III subunit C3 antibody
      • RPC3 antibody
      • RPC3_HUMAN antibody
      • RPC62 antibody
      see all

    Anti-RPC62 antibody images

    • Detection of RPC62 by Western Blot of Immunprecipitate.
      An antibody to RPC62 at 1µg/ml staining RPC62 in HeLa whole cell lysate immunoprecipitated using ab111995 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection: Chemiluminescence with exposure time of 30 seconds.

    References for Anti-RPC62 antibody (ab111995)

    ab111995 has not yet been referenced specifically in any publications.

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