• Product name
  • Description
    Goat polyclonal to RPGRIP1L
  • Host species
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide: C-


    , corresponding to internal sequence amino acids 1210-1222 of human RPGRIP1L (NP_056087.2)

  • Positive control
    • Human brain (cerebellum) lysates


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab77615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/64000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 151 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4 (By similarity). Does not seem to be strictly required for ciliogenesis.
    • Tissue specificity
      Ubiquitously expressed with relatively high level of expression in hypothalamus and islet. During early development, expressed in multiple organs including brain, eye, forelimb and kidney.
    • Involvement in disease
      Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. Single-locus allelism is insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion that variations across multiple sites of the ciliary proteome, including RPGRIP1L, influence the clinical outcome.
      Joubert syndrome 7
      Meckel syndrome 5
      COACH syndrome
    • Sequence similarities
      Belongs to the RPGRIP1 family.
      Contains 2 C2 domains.
    • Cellular localization
      Cytoplasm. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > cilium axoneme. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Cell junction > tight junction. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions.
    • Information by UniProt
    • Database links
    • Alternative names
      • CORS 3 antibody
      • CORS3 antibody
      • Fantom antibody
      • FTM antibody
      • FTM_HUMAN antibody
      • JBTS 1 antibody
      • JBTS 7 antibody
      • JBTS1 antibody
      • JBTS7 antibody
      • Joubert syndrome 1 antibody
      • Joubert syndrome 7 antibody
      • Meckel syndrome, type 1 antibody
      • Meckel syndrome, type 5 antibody
      • MKS 5 antibody
      • MKS5 antibody
      • Nephrocystin-8 antibody
      • NPHP 8 antibody
      • NPHP8 antibody
      • Protein fantom antibody
      • Retinitis pigmentosa GTPase regulator interacting protein 1 like antibody
      • RPGR interacting protein 1 like protein antibody
      • RPGR-interacting protein 1-like protein antibody
      • RPGRIP1 like protein antibody
      • RPGRIP1-like protein antibody
      • Rpgrip1l antibody
      see all


    • Anti-RPGRIP1L antibody (ab77615) at 0.3 µg + human brain (cerebellum) lysate (in RIPA buffer) at 35 µg

      Developed using the ECL technique.

      Predicted band size: 151 kDa
      Observed band size: 151 kDa

      Exposure time: 1 hour


    ab77615 has not yet been referenced specifically in any publications.

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