Overview

  • Product name
  • Description
    Rabbit polyclonal to RPIA
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Pig
  • Immunogen

    Synthetic peptide within Human RPIA aa 180-207 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: P49247

  • Positive control
    • NCI-H292 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab173640 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 33 kDa.

Target

  • Pathway
    Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.
  • Involvement in disease
    Defects in RPIA are the cause of ribose 5-phosphate isomerase deficiency (RPID) [MIM:608611]. A patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts.
  • Sequence similarities
    Belongs to the ribose 5-phosphate isomerase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 5.3.1.6 antibody
    • MGC103524 antibody
    • Phosphoriboisomerase A antibody
    • Phosphoriboisomerase antibody
    • Ribose 5 phosphate isomerase antibody
    • ribose 5-phosphate epimerase antibody
    • ribose 5-phosphate isomerase A antibody
    • Ribose-5-phosphate isomerase antibody
    • RPI antibody
    • rpiA antibody
    • RPIA_HUMAN antibody
    • zgc:103524 antibody
    see all

Images

  • Anti-RPIA antibody (ab173640) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size : 33 kDa

References

ab173640 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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