Overview

  • Product name
  • Description
    Rabbit polyclonal to RPIA
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide, corresponding to a region within N terminal amino acids 1-50 (QRPGPFSTLYGRVLAPLPGRAGGAASGGGGNSWDLPGSHVRLPGRAQSG T) of Human RPIA, NP_653164

  • Positive control
    • 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab86123 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Pathway
    Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.
  • Involvement in disease
    Defects in RPIA are the cause of ribose 5-phosphate isomerase deficiency (RPID) [MIM:608611]. A patient has been described with a deficiency of ribose 5-phosphate isomerase who presented with leukoencephalopathy and peripheral neuropathy. Proton magnetic resonance spectroscopy of the brain revealed a highly elevated level of the polyols ribitol and D-arabitol, which were subsequently also found in high concentrations in body fluids. Deficient activity of RPIA, one of the pentose phosphate pathway enzymes, has been demonstrated in fibroblasts.
  • Sequence similarities
    Belongs to the ribose 5-phosphate isomerase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC 5.3.1.6 antibody
    • MGC103524 antibody
    • Phosphoriboisomerase A antibody
    • Phosphoriboisomerase antibody
    • Ribose 5 phosphate isomerase antibody
    • ribose 5-phosphate epimerase antibody
    • ribose 5-phosphate isomerase A antibody
    • Ribose-5-phosphate isomerase antibody
    • RPI antibody
    • rpiA antibody
    • RPIA_HUMAN antibody
    • zgc:103524 antibody
    see all

Images

  • Anti-RPIA antibody (ab86123) at 1 µg/ml + 293T cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa
    Observed band size : 33 kDa

References

ab86123 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab86123.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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