Overview

  • Product name
  • Description
    Rabbit polyclonal to RRAD
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Orangutan
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human RRAD.

    (Peptide available as ab95049.)

  • Positive control
    • This antibody gave a positive signal in Human skeletal muscle tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab84109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 33 kDa).

Target

  • Function
    May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
  • Tissue specificity
    Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
  • Sequence similarities
    Belongs to the small GTPase superfamily. RGK family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • GTP binding protein RAD antibody
    • GTP-binding protein RAD antibody
    • RAD antibody
    • RAD_HUMAN antibody
    • RAD1 antibody
    • RAS (RAD and GEM) like GTP binding 3 antibody
    • Ras associated with diabetes antibody
    • Ras related associated with diabetes antibody
    • REM3 antibody
    • RRAD antibody
    see all

Images

  • Anti-RRAD antibody (ab84109) at 1 µg/ml + Human skeletal muscle tissue lysate - total protein (ab29330) at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Predicted band size : 33 kDa
    Observed band size : 33 kDa


    Exposure time : 3 minutes

References

ab84109 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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