FunctionIt is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
Tissue specificityUbiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.
Involvement in diseaseOvarian cancer
Sequence similaritiesBelongs to the small GTPase superfamily. Ras family.
Post-translational modificationsMay be post-translationally modified by both palmitoylation and polyisoprenylation.
Cellular localizationCell membrane. Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).