FunctionTranscription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.
Tissue specificityExpressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
Sequence similaritiesBelongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
ab64168 at 10µg/ml staining RREB1 in mouse kidney by Immunohistochemistry, Formalin-fixed, paraffin-embedded tissue.
References for Anti-RREB1 antibody (ab64168)
This product has been referenced in:
Kent OA et al. RREB1 repressed miR-143/145 modulates KRAS signaling through downregulation of multiple targets. Oncogene : (2012).
Read more (PubMed: 22751122) »
Pramanik D et al. Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol Cancer Ther10:1470-80 (2011).
Read more (PubMed: 21622730) »