Overview

  • Product nameAnti-RRM2 antibody
    See all RRM2 primary antibodies
  • Description
    Rabbit polyclonal to RRM2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Horse, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within the N terminal amino acids 36-85 (ALSGTRVLAS KTARRIFQEP TEPKTKAAAP GVEDEPLLRE NPRRFVIFPI) of Human RRM2 (NP_001025).

  • Positive control
    • Human fetal muscle lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab87227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionProvides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
  • PathwayGenetic information processing; DNA replication.
  • Sequence similaritiesBelongs to the ribonucleoside diphosphate reductase small chain family.
  • Post-translational
    modifications
    Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • cb111 antibody
    • chunp6884 antibody
    • etID309896.20 antibody
    • R2 antibody
    • reductase M2 polypeptide variant 1 antibody
    • reductase M2 polypeptide variant 2 antibody
    • reductase M2 polypeptide variant 3a antibody
    • reductase M2 polypeptide variant 3b antibody
    • reductase M2 polypeptide variant 3c antibody
    • reductase M2 polypeptide variant 3d antibody
    • Ribonucleoside-diphosphate reductase subunit M2 antibody
    • Ribonucleotide reductase M2 antibody
    • Ribonucleotide reductase M2 polypeptide antibody
    • Ribonucleotide reductase M2 subunit antibody
    • ribonucleotide reductase protein r2 class I antibody
    • Ribonucleotide reductase regulatory subunit M2 antibody
    • Ribonucleotide reductase small chain antibody
    • Ribonucleotide reductase small subunit antibody
    • Ribonucleotide reductase, R2 subunit antibody
    • RIR2_HUMAN antibody
    • RR2 antibody
    • RR2M antibody
    • RRM2 antibody
    see all

Anti-RRM2 antibody images

  • Anti-RRM2 antibody (ab87227) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal muscle lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 45 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 38 kDa. We are unsure as to the identity of these extra bands.

References for Anti-RRM2 antibody (ab87227)

ab87227 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"