Selective, high affinity 5-HT2C receptor antagonist
Selective, high affinity 5-HT2C receptor antagonist (pKi = 8.4). Displays approximately 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and > 100-fold selectivity over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors.
Store at room temperature (desiccating conditions).
Soluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Bell R et al. Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands. Sci Rep4:3881 (2014).
Read more (PubMed: 24457553) »
Fantegrossi WE et al. Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice. J Pharmacol Exp Ther335:728-34 (2010).
Read more (PubMed: 20858706) »
Liu FY et al. Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. J Pharmacol Exp Ther321:1046-53 (2007).
Read more (PubMed: 17329553) »