Overview

  • Product name
    RS 102221 hydrochloride
  • Description
    Selective, high affinity 5-HT2C receptor antagonist
  • Biological description

    Selective, high affinity 5-HT2C receptor antagonist (pKi = 8.4). Displays approximately 100-fold selectivity over the 5-HT2A and 5-HT2B subtypes and > 100-fold selectivity over other 5-HT receptors, α- and β-adrenergic and muscarinic ACh receptors.

  • Purity
    > 98%

Properties

  • Chemical name

    N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-
    oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)-benzenesulfonamide hydrochloride

  • Molecular weight
    649.08
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C27H31F3N4O7S.HCl
  • CAS Number
    187397-18-8
  • Storage instructions
    Store at room temperature (desiccating conditions).
  • Solubility overview

    Soluble in DMSO to 100 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Cl.FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc2cc(c(OC)cc2OC)C(=O)CCCCN4CCC3(NC(=O)NC3=O)CC4
  • Source

    Synthetic

References

This product has been referenced in:
  • Bell R  et al. Anxiolytic-like effects observed in rats exposed to the elevated zero-maze following treatment with 5-HT2/5-HT3/5-HT4 ligands. Sci Rep 4:3881 (2014). Read more (PubMed: 24457553) »
  • Fantegrossi WE  et al. Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice. J Pharmacol Exp Ther 335:728-34 (2010). Read more (PubMed: 20858706) »
  • Liu FY  et al. Roles of 5-hydroxytryptamine (5-HT) receptor subtypes in the inhibitory effects of 5-HT on C-fiber responses of spinal wide dynamic range neurons in rats. J Pharmacol Exp Ther 321:1046-53 (2007). Read more (PubMed: 17329553) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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