Overview

  • Product nameRS 102895 hydrochloride
  • Description
    Selective CCR2 receptor antagonist
  • Biological descriptionSelective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
  • Purity> 99%

Properties

  • Chemical name1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • Molecular weight426.86
  • Chemical structureChemical Structure
  • Molecular formulaC21H21F3N2O2.HCl
  • CAS Number1173022-16-6
  • Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.FC(F)(F)c1ccc(cc1)CCN2CCC4(CC2)OC(=O)Nc3ccccc34
  • Source

    Synthetic

    References for RS 102895 hydrochloride (ab120812)

    This product has been referenced in:
    • Rehni AK & Singh N Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro. Psychopharmacology (Berl) 220:427-38 (2012). Read more (PubMed: 21931991) »
    • Rehni AK & Singh TG Involvement of CCR-2 chemokine receptor activation in ischemic preconditioning and postconditioning of brain in mice. Cytokine 60:83-9 (2012). Read more (PubMed: 22704692) »
    • Mirzadegan T  et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 275:25562-71 (2000). Read more (PubMed: 10770925) »

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"