Overview

  • Product nameRS 127445 hydrochloride
  • Description
    Selective, potent 5-HT2B antagonist
  • Biological descriptionSelective and potent 5-HT2Bantagonist (pKi = 9.5). 1000-fold selectivity over 5-HT2A, 5-HT2C, 5-HT5, 5-HT6 and 5-HT7. Oral and intraperitoneal bioavailability.
  • Purity> 99%

Properties

    References for RS 127445 hydrochloride (ab120585)

    This product has been referenced in:
    • Banas SM  et al. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 36:423-33 (2011). Read more (PubMed: 20927048) »
    • Bassil AK  et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol 158:252-8 (2009). Read more (PubMed: 19371340) »
    • Bonhaus DW  et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol 127:1075-82 (1999). Read more (PubMed: 10455251) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120585.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"