Overview

  • Product name
    RS 127445 hydrochloride
  • Description
    Selective, potent 5-HT2B antagonist
  • Biological description
    Selective and potent 5-HT2Bantagonist (pKi = 9.5). 1000-fold selectivity over 5-HT2A, 5-HT2C, 5-HT5, 5-HT6 and 5-HT7. Oral and intraperitoneal bioavailability.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Banas SM  et al. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects. Neuropsychopharmacology 36:423-33 (2011). Read more (PubMed: 20927048) »
  • Bassil AK  et al. Inhibition of colonic motility and defecation by RS-127445 suggests an involvement of the 5-HT2B receptor in rodent large bowel physiology. Br J Pharmacol 158:252-8 (2009). Read more (PubMed: 19371340) »
  • Bonhaus DW  et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol 127:1075-82 (1999). Read more (PubMed: 10455251) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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