Overview

  • Product nameRS 504393
  • Description
    Highly selective CCR2 chemokine receptor antagonist
  • Biological descriptionHighly selective CCR2 chemokine receptor antagonist (IC50 = 89 nM). Shows 700-fold greater binding for CCR2 vs. CCR1. Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.
  • Purity> 98%

Properties

    References for RS 504393 (ab120813)

    This product has been referenced in:
    • Kitagawa K  et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol 165:237-46 (2004). Read more (PubMed: 15215179) »
    • Furuichi K  et al. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol 14:2503-15 (2003). Read more (PubMed: 14514728) »
    • Mirzadegan T  et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 275:25562-71 (2000). Read more (PubMed: 10770925) »

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    Product Wall

    The amount of product required depends on many factors including target accessibility, cell permeability, duration of incubation, and type of cells or assay used, it is best to survey the literature to determine the IC50, EC50 or Ki. For an inhibitor, ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"