Biological descriptionWater soluble form of (R,S)-CHPG (ab120039), a selective mGlu5 agonist.
Also available in simple stock solutions (ab144497) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name(R,S)-2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid sodium salt
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Domenici MR et al. Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson's disease. J Neurosci Res80:646-54 (2005).
Read more (PubMed: 15880742) »
Salt TE et al. Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus. Br J Pharmacol127:1057-9 (1999).
Read more (PubMed: 10455248) »
Doherty AJ et al. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology36:265-7 (1997).
Read more (PubMed: 9144665) »