Overview

  • Product name(R,S)-MCPG
  • Description
    Group I /II metabotropic glutamate antagonist
  • Biological descriptionGroup I / group II metabotropic glutamate receptor antagonist.
  • Purity> 99%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120033 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    (R,S)-MCPG images

    • ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG (ab120033), by ICC/IF. Decrease in FMRP expression correlates with increased concentration of (R,S)-MCPG, as described in literature.
      The cells were incubated at 37°C for 2h in media containing different concentrations of ab120033 ((R,S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for (R,S)-MCPG (ab120033)

    This product has been referenced in:
    • Kim JH & Vezina P The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats. Neuropharmacology 37:189-97 (1998). Read more (PubMed: 9680243) »
    • Watkins J & Collingridge G Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmacol Sci 15:333-42 (1994). Read more (PubMed: 7992387) »
    • Eaton SA  et al. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol 244:195-7 (1993). Read more (PubMed: 8381746) »

    See all 3 Publications for this product

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    There are currently no Abreviews or Questions for ab120033.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"