Overview

  • Product name
    (R,S)-MCPG sodium salt
  • Description
    Group I /II metabotropic glutamate antagonist; water soluble
  • Biological description
    Group I / group II metabotropic glutamate receptor antagonist. Water soluble form. Also available in Kit: mGlu antagonists (ab120322).

    Also available in simple stock solutions (ab146689) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity
    > 99%

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab120252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG sodium salt (ab120252), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (R,S)-MCPG sodium salt, as described in literature.
    The cells were incubated at 37°C for 2h in media containing different concentrations of ab120252 ((R,S)-MCPG sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:
  • Kim JH & Vezina P The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats. Neuropharmacology 37:189-97 (1998). Read more (PubMed: 9680243) »
  • Watkins J & Collingridge G Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmacol Sci 15:333-42 (1994). Read more (PubMed: 7992387) »
  • Eaton SA  et al. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol 244:195-7 (1993). Read more (PubMed: 8381746) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab120252.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up