Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab111068)

Overview

  • Product name
    Anti-Rsk 2 / MAPKAP Kinase 1b antibody
    See all Rsk 2 / MAPKAP Kinase 1b primary antibodies
  • Description
    Rabbit polyclonal to Rsk 2 / MAPKAP Kinase 1b
  • Tested applications
    Suitable for: WB, IP, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Sheep, Rabbit, Chicken, Guinea pig, Cow, Dog, Human, Pig, Xenopus laevis, Chimpanzee, Monkey, Zebrafish, Orangutan
  • Immunogen

    Synthetic peptide:

    LGVLLYTMLTGYTP

    , corresponding to amino acids 604-617 of Mouse Rsk 2/ MAPKAP Kinase 1b.

  • Positive control
    • Human Tonsil and Pancreas tissues.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.20
    Preservative: 0.09% Sodium azide
    Constituents: 50% Glycerol, 49.91% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111068 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 84 kDa.
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
  • Tissue specificity
    Expressed in many tissues, highest levels in skeletal muscle.
  • Involvement in disease
    Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • Post-translational
    modifications
    Autophosphorylated on Ser-386, as part of the activation process.
    Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.
  • Information by UniProt
  • Database links
  • Alternative names
    • 90 kDa ribosomal protein S6 kinase 3 antibody
    • CLS antibody
    • HU 3 antibody
    • HU2 antibody
    • HU3 antibody
    • Insulin stimulated protein kinase 1 antibody
    • Insulin-stimulated protein kinase 1 antibody
    • ISPK-1 antibody
    • ISPK1 antibody
    • KS6A3_HUMAN antibody
    • MAP kinase activated protein kinase 1b antibody
    • MAP kinase-activated protein kinase 1b antibody
    • MAPK activated protein kinase 1b antibody
    • MAPK-activated protein kinase 1b antibody
    • MAPKAP kinase 1b antibody
    • MAPKAPK 1b antibody
    • MAPKAPK-1b antibody
    • MAPKAPK1B antibody
    • Mental retardation, X linked 19 antibody
    • MRX19 antibody
    • OTTHUMP00000023036 antibody
    • p90 RSK2 antibody
    • p90 RSK3 antibody
    • p90-RSK 3 antibody
    • p90RSK3 antibody
    • pp90RSK2 antibody
    • Ribosomal protein S6 kinase 90kDa polypeptide 3 antibody
    • Ribosomal protein S6 kinase alpha 3 antibody
    • Ribosomal protein S6 kinase alpha-3 antibody
    • Ribosomal protein s6 kinase ii alpha 2 antibody
    • Ribosomal S6 kinase 2 antibody
    • Rps6ka3 antibody
    • RSK antibody
    • RSK-2 antibody
    • RSK2 antibody
    • S6 kinase 2 antibody
    • S6K alpha3 antibody
    • S6K-alpha-3 antibody
    see all

Images

  • ab111068 at 20 µg/ml staining Rsk 2 / MAPKAP Kinase 1b in formalin-fixed, paraffin-embedded Human Pancreas tissue by Immunohistochemistry followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab111068 at 20 µg/ml staining Rsk 2 / MAPKAP Kinase 1b in formalin-fixed, paraffin-embedded Human tonsil tissue by Immunohistochemistry followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

ab111068 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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