Overview

  • Product name
  • Description
    Goat polyclonal to RSK3
  • Specificity
    ab115037 is expected to recognize both reported isoforms (NP_066958.2; NP_001006933.1).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
    Predicted to work with: Mouse, Horse, Chicken, Cow, Dog, Human, Pig, Cynomolgus monkey
  • Immunogen

    Synthetic peptide:

    C-EYLSPNQLSRQDVH

    , corresponding to C terminal amino acids 676-689 of Human RSK3 (NP_066958.2).

  • Positive control
    • Rat Lung lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab115037 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 83 kDa).

Target

  • Function
    Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
  • Tissue specificity
    Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • Post-translational
    modifications
    Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1.
    N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • Cellular localization
    Nucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • 90 kDa ribosomal protein S6 kinase 2 antibody
    • HU 2 antibody
    • KS6A2_HUMAN antibody
    • MAP kinase activated protein kinase 1c antibody
    • MAP kinase-activated protein kinase 1c antibody
    • MAPK-activated protein kinase 1c antibody
    • MAPKAP kinase 1c antibody
    • MAPKAPK-1c antibody
    • MAPKAPK1C antibody
    • Mitogen.activated protein kinase-activated protein kinase 1C antibody
    • p90 RSK3 antibody
    • p90-RSK 2 antibody
    • p90RSK2 antibody
    • pp90RSK3 antibody
    • Ribosomal protein S6 kinase alpha-2 antibody
    • ribosomal protein S6 kinase, 90kDa, polypeptide 2 antibody
    • Ribosomal S6 kinase 3 antibody
    • RPS6KA2 antibody
    • RSK 3 antibody
    • RSK antibody
    • RSK-3 antibody
    • S6K alpha antibody
    • S6K alpha 2 antibody
    • S6K-alpha-2 antibody
    see all

Images

References

ab115037 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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