Recombinant
RabMAb

Anti-RSK3 antibody [E202] (ab32563)

Overview

  • Product name
    Anti-RSK3 antibody [E202]
    See all RSK3 primary antibodies
  • Description
    Rabbit monoclonal [E202] to RSK3
  • Specificity
    This antibody will detect total RSK3.
  • Tested applications
    Suitable for: WB, IHC-P, ICC, IPmore details
    Unsuitable for: Flow Cyt
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic phospho-peptide corresponding to residues surrounding Thr353 and Thr356 of human RSK3.

  • Positive control
    • Human prostate carcinoma tissue.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab32563 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/20000. Predicted molecular weight: 83 kDa.
IHC-P 1/50 - 1/100.
ICC 1/50.
IP 1/100.
  • Application notes
    Is unsuitable for Flow Cyt.
  • Target

    • Function
      Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
    • Tissue specificity
      Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
    • Sequence similarities
      Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 2 protein kinase domains.
    • Post-translational
      modifications
      Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1.
      N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
    • Cellular localization
      Nucleus. Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • 90 kDa ribosomal protein S6 kinase 2 antibody
      • HU 2 antibody
      • KS6A2_HUMAN antibody
      • MAP kinase activated protein kinase 1c antibody
      • MAP kinase-activated protein kinase 1c antibody
      • MAPK-activated protein kinase 1c antibody
      • MAPKAP kinase 1c antibody
      • MAPKAPK-1c antibody
      • MAPKAPK1C antibody
      • Mitogen.activated protein kinase-activated protein kinase 1C antibody
      • p90 RSK3 antibody
      • p90-RSK 2 antibody
      • p90RSK2 antibody
      • pp90RSK3 antibody
      • Ribosomal protein S6 kinase alpha-2 antibody
      • ribosomal protein S6 kinase, 90kDa, polypeptide 2 antibody
      • Ribosomal S6 kinase 3 antibody
      • RPS6KA2 antibody
      • RSK 3 antibody
      • RSK antibody
      • RSK-3 antibody
      • S6K alpha antibody
      • S6K alpha 2 antibody
      • S6K-alpha-2 antibody
      see all

    Images

    • Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using ab32563 at 1/50 dilution.

    References

    ab32563 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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