Anti-RUNX1T1 / ETO antibody (ab124269)

Overview

• Product name
  Anti-RUNX1T1 / ETO antibody
  See all RUNX1T1 / ETO primary antibodies
• Description
  Rabbit polyclonal to RUNX1T1 / ETO
• Tested applications
  Suitable for: WB, IPmore details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
• Immunogen

  Synthetic peptide, corresponding to a region within amino acids 554-604 of Human RUNX1T1/ ETO (NP_001185555.1).

• Positive control
  • Purchase matching WB positive control:Recombinant Human RUNX1T1 / ETO protein
  • 293T whole cell lysate

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  Preservative: 0.09% Sodium azide
  Constituent: 99% Tris citrate/phosphate
  Note: pH 7 to 8
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Purification notes
  ab124269 was affinity purified using an epitope specific to RUNX1T1 / ETO immobilized on solid support.
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Zinc Finger

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Transcription Factors

  • Cancer
  • Oncoproteins/suppressors
  • Tumor suppressors
  • Other

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • 293T whole cell lysate (ab95494)

Applications

Target

• Function
  Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.
• Tissue specificity
  Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
• Involvement in disease
  Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.
  Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:114500].
• Sequence similarities
  Belongs to the CBFA2T family.
  Contains 1 MYND-type zinc finger.
  Contains 1 TAFH (NHR1) domain.
• Domain
  The TAFH domain mediates interaction with transcription regulators.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession Q06455 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 862 Human
  • Entrez Gene: 12395 Mouse
  • Entrez Gene: 362489 Rat
  • Omim: 133435 Human
  • SwissProt: Q06455 Human
  • SwissProt: Q61909 Mouse
  • Unigene: 368431 Human
  • Unigene: 470961 Mouse

  • Unigene: 4909 Mouse
  • Unigene: 218117 Rat

  see all
• Alternative names
  • Acute myelogenous leukemia 1 translocation 1 cyclin D related antibody
  • Acute myelogenous leukemia 1 translocation 1 protein antibody
  • AML1 MTG8 antibody

  • AML1T1 antibody
  • CBFA2T1 antibody
  • CDR antibody
  • Core binding factor runt domain alpha subunit 2 translocated to 1 antibody
  • Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related antibody
  • Cyclin D related antibody
  • Cyclin D related protein antibody
  • Cyclin-D-related protein antibody
  • Eight twenty one protein antibody
  • ETO antibody
  • ETO protein antibody
  • MGC2796 antibody
  • MTG 8 antibody
  • MTG 8b antibody
  • MTG8 antibody
  • MTG8 protein antibody
  • MTG8_HUMAN antibody
  • MTG8b antibody
  • Myeloid translocation gene on 8q22 antibody
  • Protein CBFA2T1 antibody
  • Protein ETO antibody
  • Protein MTG 8 antibody
  • Protein MTG8 antibody
  • Runt related transcription factor 1 translocated to 1 (cyclin D related) antibody
  • Runt related transcription factor 1 translocated to 1 antibody
  • Runt related transcription factor 1 translocated to 1 cyclin D related antibody
  • RUNX1 translocation partner 1 antibody
  • RUNX1T1 antibody
  • Zinc finger MYND domain containing protein 2 antibody
  • Zinc finger MYND domain-containing protein 2 antibody
  • ZMYND 2 antibody
  • ZMYND2 antibody

  see all

Protocols

• Western blot protocols
• Immunoprecipitation protocols