Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab124269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000.
IP Use at 2-10 µg/mg of lysate.

Target

  • FunctionTranscription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.
  • Tissue specificityMost abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.
  • Involvement in diseaseNote=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.
    Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:114500].
  • Sequence similaritiesBelongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • DomainThe TAFH domain mediates interaction with transcription regulators.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Acute myelogenous leukemia 1 translocation 1 cyclin D related antibody
    • Acute myelogenous leukemia 1 translocation 1 protein antibody
    • AML1T1 antibody
    • CBFA2T1 antibody
    • CDR antibody
    • Core binding factor runt domain alpha subunit 2 translocated to 1 antibody
    • Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related antibody
    • Cyclin D related antibody
    • Cyclin D related protein antibody
    • Cyclin-D-related protein antibody
    • Eight twenty one protein antibody
    • ETO antibody
    • ETO protein antibody
    • MGC2796 antibody
    • MTG 8 antibody
    • MTG 8b antibody
    • MTG8 antibody
    • MTG8 protein antibody
    • MTG8_HUMAN antibody
    • MTG8b antibody
    • Myeloid translocation gene on 8q22 antibody
    • Protein CBFA2T1 antibody
    • Protein ETO antibody
    • Protein MTG 8 antibody
    • Protein MTG8 antibody
    • Runt related transcription factor 1 translocated to 1 (cyclin D related) antibody
    • Runt related transcription factor 1 translocated to 1 antibody
    • Runt related transcription factor 1 translocated to 1 cyclin D related antibody
    • RUNX1T1 antibody
    • Zinc finger MYND domain containing protein 2 antibody
    • Zinc finger MYND domain-containing protein 2 antibody
    • ZMYND 2 antibody
    • ZMYND2 antibody
    see all

Anti-RUNX1T1 / ETO antibody images

  • All lanes : Anti-RUNX1T1 / ETO antibody (ab124269) at 0.4 µg/ml

    Lane 1 : 293T whole cell lysate at 50 µg
    Lane 2 : 293T whole cell lysate at 15 µg
    Lane 3 : Jurkat whole cell lysate at 50 µg
    Lane 4 : HeLa whole cell lysate at 50 µg

    Developed using the ECL technique

    Exposure time : 30 seconds
  • ab124269 at 1 µg/ml staining RUNX1T1 / ETO in 293T whole cell lysate immunoprecipitated using ab124269 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Lane 2: control IgG. Predicted band size : 68 kDa. Exposure time: 30 seconds

References for Anti-RUNX1T1 / ETO antibody (ab124269)

ab124269 has not yet been referenced specifically in any publications.

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