Overview

  • Product name
    Anti-RuvC antibody [RuvC 7F1/5]
    See all RuvC primary antibodies
  • Description
    Mouse monoclonal [RuvC 7F1/5] to RuvC
  • Tested applications
    Suitable for: ELISA, WB, IPmore details
  • Immunogen

    Ruv C protein from E. Coli.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    RuvC 7F1/5
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab81920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

Target

  • Relevance
    In Escherichia coli, the RuvA, RuvB and RuvC proteins are required for the late stages of homologous recombination and DNA repair. They are involved in processing the Holliday junction during homologous recombination. RuvA protein binds to both single-stranded and double stranded DNA and enhances ATPase activity of RuvB. RuvA and RuvB promote branch migration whereas RuvC resolves junctions by endonucleolytic cleavage. Moreover RuvAB stimulate Holliday junction resolution by RuvC. The RuvA-RuvB complex interacts with an irregular conformation in damaged DNA and induces conformational changes in DNA using energy provided by ATP hydrolysis, so that it facilitates DNA repair, recombination and error prone replication. RuvABC proteins are responsible for the occurrence of DSBs at arrested replication forks. In cells proficient for RecBC, RuvAB is uncoupled from RuvC and DSBs may be prevented.
  • Alternative names
    • Crossover junction endodeoxyribonuclease ruvC antibody
    • Holliday junction nuclease ruvC antibody
    • Holliday junction resolvase ruvC antibody

References

ab81920 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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