Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab6097 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes

    Stable for one year.

    Cell death signal are transduced by Death Domain (DD), Death Effector Domain (DED), and Caspase Recruitment Domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA binding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • 2410018J24Rik
    • AAP 1
    • AAP1
    • APAP 1
    • APAP-1
    • APAP1
    • Apoptin associating protein 1
    • Apoptin-associating protein 1
    • cb337
    • Death effector domain associated factor
    • Death effector domain-associated factor
    • Death effector domain-associated factor B
    • DED associated factor
    • DED-associated factor
    • DED-associated factor B
    • DEDAF
    • MGC62213
    • RING1 and YY1 binding protein
    • RING1 and YY1 binding protein a
    • RING1 and YY1-binding protein
    • RING1 and YY1-binding protein B
    • Ring1 interactor RYBP
    • RYBP
    • RYBP_HUMAN
    • rybpa
    • wu:fi34f03
    • YEAF 1
    • YEAF1
    • YY1 and E4TF1 associated factor 1
    • YY1 and E4TF1-associated factor 1
    • YY1- and E4TF1/GABP-associated factor 1
    • zgc:153842
    see all
  • FunctionMay be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, may induce apoptosis.
  • Tissue specificityWidely expressed with highest levels in lymphoid tissues and placenta.
  • Sequence similaritiesContains 1 RanBP2-type zinc finger.
  • Cellular localizationNucleus. Cytoplasm. Primarily found in the nucleus.
  • Information by UniProt

References for RYBP peptide (ab6097)

ab6097 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"