Overview

  • Product nameAnti-RYK antibody
    See all RYK primary antibodies
  • Description
    Rabbit polyclonal to RYK
  • Tested applicationsSuitable for: IHC-P, ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to amino acids 576-592 of Human RYK.

  • Positive control
    • Jurkat cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab5518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100.
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 67.5 kDa (predicted molecular weight: 72 kDa).

Target

  • FunctionMay be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
  • Tissue specificityObserved in all the tissues examined.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 protein kinase domain.
    Contains 1 WIF domain.
  • DomainThe extracellular WIF domain is responsible for Wnt binding.
  • Post-translational
    modifications
    Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
  • Cellular localizationMembrane. Nucleus. Cytoplasm. In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • D3S3195 antibody
    • ERK 3 antibody
    • Hydroxyaryl protein kinase antibody
    • JTK 5 antibody
    • JTK 5A antibody
    • JTK5 antibody
    • JTK5A antibody
    • JTK5A protein tyrosine kinase antibody
    • receptor like tyrosine kinase antibody
    • receptor like tyrosine kinase precursor antibody
    • RYK 1 antibody
    • Ryk antibody
    • RYK_HUMAN antibody
    • RYK1 antibody
    • Tyrosine protein kinase RYK antibody
    • Tyrosine protein kinase RYK precursor antibody
    • Tyrosine-protein kinase RYK antibody
    • Vik antibody
    see all

Anti-RYK antibody images



  • Predicted band size : 72 kDa


    ab5518 at a 1/100 dilution staining approximately 67.5kDa band of RYK in Jurkat cell lysate by Western blot (ECL).
  • ab5518 staining RYK in human hepatocarcinoma (HC) tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

References for Anti-RYK antibody (ab5518)

ab5518 has not yet been referenced specifically in any publications.

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