Anti-S adenosylhomocysteine hydrolase antibody (ab187518)

Overview

  • Product name
    Anti-S adenosylhomocysteine hydrolase antibody
    See all S adenosylhomocysteine hydrolase primary antibodies
  • Description
    Rabbit polyclonal to S adenosylhomocysteine hydrolase
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human S adenosylhomocysteine hydrolase (C terminal). C-terminal 180AA
    Database link: P23526

  • Positive control
    • 22RV-1, SW480, HepG2, U937, SW620, MCF-7, K562 and Mouse liver cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab187518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 48 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function
    Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
  • Pathway
    Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
  • Involvement in disease
    Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) [MIM:613752]. A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.
  • Sequence similarities
    Belongs to the adenosylhomocysteinase family.
  • Cellular localization
    Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenosylhomocysteinase antibody
    • AdoHcyase antibody
    • ahcY antibody
    • S adenosyl L homocysteine hydrolase antibody
    • S adenosylhomocysteine hydrolase antibody
    • S-adenosyl-L-homocysteine hydrolase antibody
    • SAHH antibody
    • SAHH_HUMAN antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung tissue labelling S adenosylhomocysteine hydrolase with ab187518 at 1/200. Magnification: 200x.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast cancer tissue labelling S adenosylhomocysteine hydrolase with ab187518 at 1/200. Magnification: 200x.
  • All lanes : Anti-S adenosylhomocysteine hydrolase antibody (ab187518) at 1/500 dilution

    Lane 1 : 22RV-1 cell extracts
    Lane 2 : SW480 cell extracts
    Lane 3 : HepG2 cell extracts
    Lane 4 : U937 cell extracts
    Lane 5 : SW620 cell extracts
    Lane 6 : MCF-7 cell extracts
    Lane 7 : K562 cell extracts
    Lane 8 : Mouse liver cell extracts


    Predicted band size : 48 kDa

References

ab187518 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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