Overview

  • Product name(S)-MCPG
  • Description
    Group I / II mGlu antagonist
  • Biological descriptionActive isomer of (R,S)-MCPG (ab120033). Group I / II mGlu receptor antagonist with some activity reported at mGlu8.

    Also available in simple stock solutions (ab146674) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 98%

Properties

    Associated products

    Applications

    Our Abpromise guarantee covers the use of ab120059 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    (S)-MCPG images

    • ab17722 staining FMRP in SK-N-SH cells treated with (S)-MCPG (ab120059), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (S)-MCPG, as described in literature.
      The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120059 ((S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for (S)-MCPG (ab120059)

    This product has been referenced in:
    • Schoepp DD  et al. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431-76 (1999). Read more (PubMed: 10530808) »
    • Sekiyama N  et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol 117:1493-503 (1996). Read more (PubMed: 8730745) »
    • Bedingfield JS  et al. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br J Pharmacol 116:3323-9 (1995). Read more (PubMed: 8719814) »
    • Thomsen C  et al. Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. Eur J Pharmacol 267:77-84 (1994). Read more (PubMed: 7515823) »

    See all 9 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"