Overview

  • Product name
    (S)-MCPG
  • Description
    Group I / II mGlu antagonist
  • Biological description

    Active isomer of (R,S)-MCPG (ab120033). Group I / II mGlu receptor antagonist with some activity reported at mGlu8.

  • Purity
    > 98%

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab120059 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.

Images

  • ab17722 staining FMRP in SK-N-SH cells treated with (S)-MCPG (ab120059), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (S)-MCPG, as described in literature.
    The cells were incubated at 37°C for 30 minutes in media containing different concentrations of ab120059 ((S)-MCPG) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

References

This product has been referenced in:
  • Schoepp DD  et al. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38:1431-76 (1999). Read more (PubMed: 10530808) »
  • Sekiyama N  et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br J Pharmacol 117:1493-503 (1996). Read more (PubMed: 8730745) »
  • Bedingfield JS  et al. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br J Pharmacol 116:3323-9 (1995). Read more (PubMed: 8719814) »
  • Thomsen C  et al. Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family. Eur J Pharmacol 267:77-84 (1994). Read more (PubMed: 7515823) »

See all 9 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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