Biological descriptionHigh affinity (Kd = 1.2 nM) and high selectivity for D2 receptors in vitro and in vivo (IC50 = 32 nM). Centrally active following systemic administration.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Ogren SO et al. The selective dopamine D2 receptor antagonist raclopride discriminates between dopamine-mediated motor functions. Psychopharmacology (Berl)90:287-94 (1986).
Read more (PubMed: 2947255) »
Köhler C et al. Specific in vitro and in vivo binding of 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain. Biochem Pharmacol34:2251-9 (1985).
Read more (PubMed: 4015674) »