Glutamate receptor agonist. Glutamate analog. Precursor to L-cysteine. Assumed to cause NMDA receptor-mediated neurodegeneration in molybdenum cofactor deficiency (MoCD) patients. May be involved in cysteine-induced neurotoxicity.
S-Sulfo-L-cysteine sodium salt
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Belaidi AA & Schwarz G Molybdenum cofactor deficiency: metabolic link between taurine and S-sulfocysteine. Adv Exp Med Biol776:13-9 (2013).
Read more (PubMed: 23392866) »
Nakatani T et al. Enhancement of thioredoxin/glutaredoxin-mediated L-cysteine synthesis from S-sulfocysteine increases L-cysteine production in Escherichia coli. Microb Cell Fact11:62 (2012).
Read more (PubMed: 22607201) »
Abbas AK et al. S-sulfo-cysteine is an endogenous amino acid in neonatal rat brain but an unlikely mediator of cysteine neurotoxicity. Neurochem Res33:301-7 (2008).
Read more (PubMed: 17764028) »