The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
FunctionWeakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.
Tissue specificityHighly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
Sequence similaritiesBelongs to the S-100 family. Contains 2 EF-hand domains.
ab15520 staining S100 at 1/100 dilution in human melanoma by Immunohistochemistry (formalin/paraffin).
References for Anti-S100 antibody (ab15520)
This product has been referenced in:
Zhu L et al. Surgical monotherapy may be a suitable therapeutic strategy for advanced collecting (Bellini) duct carcinoma: A case report and literature review. Exp Ther Med12:1181-1184 (2016).
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