Overview

  • Product name
  • Description
    Rabbit polyclonal to S100 beta
  • Specificity
    Does not cross react with other calcium binding proteins including calbindin, calretinin or parvalbumins.
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: IHC-Fr
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Full length native protein homodimer (purified) (Human) (Peptide available as ab30380.)

  • Positive control
    • Rat brain tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab14688 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP 1/250.
  • Application notes
    Is unsuitable for IHC-Fr.
  • Target

    • Function
      Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
    • Tissue specificity
      Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.
    • Sequence similarities
      Belongs to the S-101 family.
      Contains 2 EF-hand domains.
    • Cellular localization
      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • NEF antibody
      • Protein S100 B antibody
      • Protein S100-B antibody
      • S 100 calcium binding protein beta chain antibody
      • S 100 protein beta chain antibody
      • S-100 protein beta chain antibody
      • S-100 protein subunit beta antibody
      • S100 antibody
      • S100 calcium binding protein beta (neural) antibody
      • S100 calcium-binding protein B antibody
      • S100 protein beta chain antibody
      • S100B antibody
      • S100B_HUMAN antibody
      • S100beta antibody
      see all

    References

    This product has been referenced in:

    See all 3 Publications for this product

    Customer reviews and Q&As

    Thank you for contacting us.  Unfortunately, I was unable to locate any amino acid sequences for Tilapia S100, S100 beta, or Dopamine D2 Receptor with which to compare the immunogen sequences for these antibodies.  For this reason, we have no informati...

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    Abcam has not validated the combination of species/application used in this Abreview.
    Application
    Immunohistochemistry (Frozen sections)
    Sample
    Rat Tissue sections (Adult rat brain)
    Specification
    Adult rat brain
    Fixative
    Paraformaldehyde
    Permeabilization
    No
    Username

    Dr. Sophie Pezet

    Verified customer

    Submitted Aug 29 2007

    I am sorry to hear that you have been having difficulties with this antibody. I have read your technical questionnaire and I have a few comments. S100 beta is a very small protein. It can be difficult to detect small proteins by using western blott...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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