Anti-S100A12/CGRP antibody (ab37657)
Key features and details
- Rabbit polyclonal to S100A12/CGRP
- Suitable for: IHC-Fr, WB
- Reacts with: Human, Recombinant fragment
- Isotype: IgG
Overview
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Product name
Anti-S100A12/CGRP antibody
See all S100A12/CGRP primary antibodies -
Description
Rabbit polyclonal to S100A12/CGRP -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Fr, WBmore details -
Species reactivity
Reacts with: Human, Recombinant fragment -
Immunogen
Fusion protein corresponding to Human S100A12/CGRP.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 50% Glycerol, PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab37657 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-Fr |
1/2000.
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WB |
1/1000 - 1/10000. Detects a band of approximately 10.5 kDa (predicted molecular weight: 10.5 kDa).
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Notes |
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IHC-Fr
1/2000. |
WB
1/1000 - 1/10000. Detects a band of approximately 10.5 kDa (predicted molecular weight: 10.5 kDa). |
Target
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Function
Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. Binds calcium, zinc and copper. Presence of zinc increases the affinity for calcium. Plays an important role in the inflammatory response. Interaction with AGER on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. -
Tissue specificity
Monocytes and lymphocytes. -
Sequence similarities
Belongs to the S-101 family.
Contains 2 EF-hand domains. - Information by UniProt
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Database links
- Entrez Gene: 6283 Human
- Omim: 603112 Human
- SwissProt: P80511 Human
- Unigene: 19413 Human
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Alternative names
- CAAF1 antibody
- CAGC antibody
- Calcitermin antibody
see all
Images
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Anti-S100A12/CGRP antibody (ab37657) detects macrophage infiltrates expressing S100A12/CGRP in colon tissues from a patient with Crohn’s disease.
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Anti-S100A12/CGRP antibody (ab37657) + 200 ng recombinant human S100A12/CGRP
Secondary
anti-rabbit IgG alkalind phosphatase conjugate
Predicted band size: 10.5 kDa
Observed band size: 10.5 kDa
Additional bands at: 21 kDa (possible dimer)
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (11)
ab37657 has been referenced in 11 publications.
- Zhang J et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res 14:6633-6656 (2021). PubMed: 34908863
- Zeng Z et al. Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma. Front Oncol 10:836 (2020). PubMed: 32528897
- Wang Q et al. Quantitative proteomic analysis of urinary exosomes in kidney stone patients. Transl Androl Urol 9:1572-1584 (2020). PubMed: 32944520
- Wu DM et al. S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. J Cell Mol Med 22:2378-2389 (2018). WB ; Mouse . PubMed: 29441717
- Bouvet GF et al. DNA Methylation Regulates RGS2-induced S100A12 Expression in Airway Epithelial Cells. Am J Respir Cell Mol Biol 59:601-613 (2018). PubMed: 29944393