For the best experience on the Abcam website please upgrade to a modern browser such as
Storage instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage buffer Preservative: 0.09% Sodium Azide
Concentration information loading...
Purity Protein G purified
Purification notes This antibody is eluted out with both high and low pH buffers, neutralized immediately after elution then followed by dialysis against PBS.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 38 kDa.
1/50 - 1/100.
Function The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Tissue specificity Expression level increases during S phase and drops in G2 phase (at protein level).
Pathway Protein modification; protein sumoylation.
Sequence similarities Belongs to the ubiquitin-activating E1 family.
Post-translational modifications Phosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localization Nucleus.
Information by UniProt
Activator of SUMO1 antibody
Anti-SAE1 antibody images
Western blot - Aos1 + Uba2 antibody (ab38434)
Anti-SAE1 antibody (ab38434) + Mouse heart tissue lysate Predicted band size : 38 kDa Additional bands at : 59 kDa,70 kDa,75 kDa. We are unsure as to the identity of these extra bands.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Aos1 + Uba2 antibody (ab38434)
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with ab38434, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining
References for Anti-SAE1 antibody (ab38434)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"