Overview

  • Product nameAnti-SAE1 antibody
    See all SAE1 primary antibodies
  • Description
    Mouse monoclonal to SAE1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-347 of Human SAE1

Properties

Applications

Our Abpromise guarantee covers the use of ab56957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionThe heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
    • Tissue specificityExpression level increases during S phase and drops in G2 phase (at protein level).
    • PathwayProtein modification; protein sumoylation.
    • Sequence similaritiesBelongs to the ubiquitin-activating E1 family.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activator of SUMO1 antibody
      • AOS1 antibody
      • HSPC140 antibody
      • Sae1 antibody
      • SAE1_HUMAN antibody
      • Sentrin/SUMO activating protein AOS1 antibody
      • SUA1 antibody
      • SUMO 1 activating enzyme E1 N subunit antibody
      • SUMO 1 activating enzyme subunit 1 antibody
      • SUMO-activating enzyme subunit 1 antibody
      • Ubiquitin like protein SUMO1 activating enzyme antibody
      • Ubiquitin-like 1-activating enzyme E1A antibody
      • UBL E1A antibody
      • UBLE1A antibody
      see all

    Anti-SAE1 antibody images



    • Predicted band size : 38 kDa
      SAE1 antibody (ab56957) at 1ug/lane + HeLa cell lysate at 25ug/lane.
    • SAE1 antibody (ab56957) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human adrenal gland.

    References for Anti-SAE1 antibody (ab56957)

    This product has been referenced in:

    See all 2 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"