For the best experience on the Abcam website please upgrade to a modern browser such as
Rabbit polyclonal to SAE1 (phospho S185)
ab106096 shows minimal reactivity by ELISA against the non-phosphorylated form of the immunising peptide
Predicted to work with:
Mouse, Rat, Cow, Dog, Chimpanzee
A synthetic peptide corresponding to a region surrounding serine 185 of Human SAE1.
HeLa cells treated with phosphatase inhibitors.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Sodium azide Constituents: 0.88% Sodium chloride, 0.42% Potassium phosphate
Concentration information loading...
Protein A purified
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 38 kDa.
1/5000 - 1/25000.
The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Expression level increases during S phase and drops in G2 phase (at protein level).
Protein modification; protein sumoylation.
Belongs to the ubiquitin-activating E1 family.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Information by UniProt
Activator of SUMO1 antibody
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"