Overview

  • Product name
  • Description
    Rabbit polyclonal to SAFB
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Chimpanzee, Rhesus monkey, Gorilla, Chinese hamster, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within residues 875 and the C-terminus (residue 915) of human SAFB (NP_002958.2).

  • Positive control
    • Human breast adenocarcinoma. Mouse squamous cell carcinoma.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab84378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500.
    Antigen exposure is recommended.
    Antigen exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation.
    • Tissue specificity
      Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
    • Sequence similarities
      Contains 1 RRM (RNA recognition motif) domain.
      Contains 1 SAP domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp779C1727 antibody
      • glutathione S transferase fusion protein antibody
      • HAP antibody
      • HET antibody
      • HSP27 ERE TATA binding protein antibody
      • HSP27 ERE-TATA-binding protein antibody
      • HSP27 estrogen response element-TATA box-binding protein antibody
      • SAF B antibody
      • SAF-B antibody
      • SAF-B1 antibody
      • SAFB 1 antibody
      • SAFB antibody
      • SAFB1 antibody
      • SAFB1_HUMAN antibody
      • Scaffold attachment factor B1 antibody
      see all

    Images

    • ab84378 at 1/250, staining human SAFB in a section of human breast adenocarcinoma by immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
    • ab84378 at 1/250 dilution, staining SAFB in FFPE section of mouse squamous cell carcinoma, by immunohistochemistry (formalin/PFA-fixed parafin-embedded sections)

    References

    ab84378 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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