Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab31905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesThis antibody gave a positive result in ELISA against the immunizing peptide (ab31904).

    Customer abreview data indicates that this antibody works in Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) on mouse tissue.

    Not yet tested in other applications.

  • Target

    • FunctionTranscriptional repressor involved in organogenesis.
    • Tissue specificityHighest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver.
    • Involvement in diseaseDefects in SALL1 are the cause of Townes-Brocks syndrome (TBS) [MIM:107480]. TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss.
      Defects in SALL1 may cause a phenotype overlapping with TBS, similar to bronchio-oto-renal syndrome (BOR) [MIM:113650]. BOR is an autosomal dominant disorder, manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation.
    • Sequence similaritiesBelongs to the sal C2H2-type zinc-finger protein family.
      Contains 9 C2H2-type zinc fingers.
    • Developmental stageIn fetal brain exclusively in neurons of the subependymal region of hypothalamus lateral to the third ventricle.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • HSal1 antibody
      • Sal like protein 1 antibody
      • Sal-1 antibody
      • Sal-like protein 1 antibody
      • Sal1 antibody
      • SALL1 antibody
      • SALL1_HUMAN antibody
      • Spalt-like transcription factor 1 antibody
      • TBS antibody
      • Zinc finger protein 794 antibody
      • Zinc finger protein SALL1 antibody
      • Zinc finger protein Spalt-1 antibody
      see all

    References for Anti-SALL1 antibody (ab31905)

    ab31905 has not yet been referenced specifically in any publications.

    Product Wall

    Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample Mouse Tissue sections (Brain)
    Specification Brain
    Fixative Formaldehyde
    Antigen retrieval step Heat mediated - Buffer/Enzyme Used: Citrate
    Permeabilization No
    Blocking step BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 2%
    Username

    Abcam user community

    Verified customer

    Submitted Jan 09 2008

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"