Anti-SALL1 antibody [K9814] (ab41974)
Key features and details
- Mouse monoclonal [K9814] to SALL1
- Suitable for: IHC-P
- Reacts with: Mouse
- Isotype: IgG2a
Overview
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Product name
Anti-SALL1 antibody [K9814]
See all SALL1 primary antibodies -
Description
Mouse monoclonal [K9814] to SALL1 -
Host species
Mouse -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Baculovirus-expressed recombinant fragment, corresponding to amino acids 258/499 of Human SALL1
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General notes
This product was changed from ascites to tissue culture supernatant on 3rd April 2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
K9814 -
Myeloma
NS1 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab41974 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P | (1) |
Use at an assay dependent concentration.
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Notes |
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IHC-P
Use at an assay dependent concentration. |
Target
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Function
Transcriptional repressor involved in organogenesis. -
Tissue specificity
Highest levels in kidney. Lower levels in adult brain (enriched in corpus callosum, lower expression in substantia nigra) and liver. -
Involvement in disease
Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS) [MIM:107480]. TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss.
Defects in SALL1 may cause a phenotype overlapping with TBS, similar to bronchio-oto-renal syndrome (BOR) [MIM:113650]. BOR is an autosomal dominant disorder, manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to Mondini type cochlear defect and stapes fixation. -
Sequence similarities
Belongs to the sal C2H2-type zinc-finger protein family.
Contains 9 C2H2-type zinc fingers. -
Developmental stage
In fetal brain exclusively in neurons of the subependymal region of hypothalamus lateral to the third ventricle. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 58198 Mouse
- SwissProt: Q9ER74 Mouse
- Unigene: 214361 Mouse
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Alternative names
- HSal1 antibody
- Sal like protein 1 antibody
- Sal-1 antibody
see all
Images
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Ab41974 staining SALL1 in Mouse embryonic kidney at tissue sections by Immunohistochemistry (IHC- P- paraformaldehyde-fixed, paraffin- embedded sections). Tissue was fixed with paraformaldehyde and blocked with 10µg/ml BSA for 1 hour at 25oC; antigen retrieval was by heat mediation in a Tris/EDTA (pH9). Samples were incubated with primary antibody (1/100 with 6% Horse serum in PBST) for 16hours at 4oC. An Alexa Fluor® 568 donkey anti-mouse polyclonal (1/500 dilution) was used as the secondary antibody.
This image was generated using the ascites version of the product.
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ab41974 staining SALL1 in Mouse embryo kidnet tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections).
This image was generated using the ascites version of the product.
Datasheets and documents
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SDS download
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Datasheet download
References (5)
ab41974 has been referenced in 5 publications.
- Qiu Z et al. The significance of glycolysis index and its correlations with immune infiltrates in Alzheimer's disease. Front Immunol 13:960906 (2022). PubMed: 36353631
- Pantier R et al. SALL4 controls cell fate in response to DNA base composition. Mol Cell 81:845-858.e8 (2021). PubMed: 33406384
- Qian C et al. Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis. Pathol Oncol Res 27:587130 (2021). PubMed: 34257535
- Hernandez JOR et al. A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo. Nat Commun 12:6496 (2021). PubMed: 34764250
- Salman H et al. SALL1 expression in acute myeloid leukemia. Oncotarget 9:7442-7452 (2018). PubMed: 29484122