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Function
Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.
Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.
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Tissue specificity
Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.
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Sequence similarities
Belongs to the KHDRBS family.
Contains 1 KH domain.
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Developmental stage
Isoform 3 is only expressed in growth-arrested cells.
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Domain
The KH domain is required for binding to RNA.
The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions.
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Post-translational
modifications
Tyrosine phosphorylated by several non-receptor tyrosine kinases, for example LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins.
Acetylated. Positively correlates with ability to bind RNA.
Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30.
Arg-291, Arg-331 and Arg-346 are found to be also dimethylated, probably to asymmetric dimethylarginine.
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Cellular localization
Nucleus. Membrane.
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Information by UniProt
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Database links
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Alternative names
- FLJ34027 antibody
- GAP associated tyrosine phosphoprotein p62 antibody
- GAP-associated tyrosine phosphoprotein p62 antibody
- KH domain containing RNA binding signal transduction associated 1 antibody
- KH domain-containing antibody
- KHDR1_HUMAN antibody
- Khdrbs1 antibody
- p21 Ras GTPase activating protein associated p62 antibody
- p21 Ras GTPase-activating protein-associated p62 antibody
- p62 antibody
- p68 antibody
- RNA-binding antibody
- Sam68 antibody
- signal transduction-associated protein 1 antibody
- Src associated in mitosis 68 kDa protein antibody
- Src-associated in mitosis 68 kDa protein antibody
see all