• Product name
    Anti-SAP97 antibody [RPI 197.4]
    See all SAP97 primary antibodies
  • Description
    Mouse monoclonal [RPI 197.4] to SAP97
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    N-Terminal truncated recombinant rat SAP97 tagged fusion protein

  • Positive control
    • Rat and mouse Brain Tissue Extract
  • General notes

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.



Our Abpromise guarantee covers the use of ab69737 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Detects a band of approximately 97, 140 kDa (predicted molecular weight: 97 , 140 kDa).


  • Function
    Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.
  • Tissue specificity
    Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Widely expressed, with isoforms displaying different expression profiles.
  • Sequence similarities
    Belongs to the MAGUK family.
    Contains 1 guanylate kinase-like domain.
    Contains 1 L27 domain.
    Contains 3 PDZ (DHR) domains.
    Contains 1 SH3 domain.
  • Domain
    The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells.
    The PDZ domains may also mediate association to membranes by binding to EPB41 and ADGRA2 together with the L27 domain that binds CASK and DLG2.
    The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization.
  • Post-translational
    Phosphorylated by MAPK12. Phosphorylation of Ser-232 regulates association with GRIN2A.
  • Cellular localization
    Membrane. Basolateral cell membrane. Endoplasmic reticulum membrane. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Cell membrane, sarcolemma. Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity).
  • Information by UniProt
  • Database links
  • Alternative names
    • Discs large homolog 1 antibody
    • discs large, Drosophila, homolog of, 1 antibody
    • discs, large homolog 1 (Drosophila) antibody
    • Disks large homolog 1 antibody
    • dJ1061C18.1.1 antibody
    • DKFZp761P0818 antibody
    • DKFZp781B0426 antibody
    • DLG 1 antibody
    • DLG1 antibody
    • DLG1_HUMAN antibody
    • DLGH 1 antibody
    • DLGH1 antibody
    • hDlg antibody
    • Presynaptic protein SAP97 antibody
    • SAP 97 antibody
    • SAP-97 antibody
    • SAP97 antibody
    • Synapse associated protein 97 antibody
    • Synapse-associated protein 97 antibody
    see all


  • All lanes : Anti-SAP97 antibody [RPI 197.4] (ab69737) at 1/1000 dilution

    Lane 1 : Rat Brain Tissue Extract
    Lane 2 : Mouse Brain Tissue Extract

    Developed using the ECL technique.

    Predicted band size: 97 , 140 kDa
    Observed band size: 140,97 kDa (why is the actual band size different from the predicted?)


This product has been referenced in:
  • van Ree JH  et al. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol 18:814-21 (2016). Read more (PubMed: 27240320) »

See 1 Publication for this product

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