Overview

  • Product name
  • Description
    Rabbit polyclonal to SAPK3
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    KLH conjugated synthetic peptide, selected from aa 351~367 of human SAPK3.

  • Positive control
    • Mouse muscle tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab37932 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 42 kDa.

Target

  • Function
    Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation.
  • Tissue specificity
    Highly expressed in skeletal muscle and heart.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
    Contains 1 protein kinase domain.
  • Domain
    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Post-translational
    modifications
    Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme.
  • Cellular localization
    Cytoplasm. Mitochondrion. Mitochondrial when associated with SH3BP5.
  • Information by UniProt
  • Database links
  • Alternative names
    • ERK 6 antibody
    • ERK-6 antibody
    • ERK6 antibody
    • Extracellular signal-regulated kinase 6 antibody
    • MAP kinase 12 antibody
    • MAP kinase p38 gamma antibody
    • MAPK 12 antibody
    • Mapk12 antibody
    • Mitogen Activated Protein Kinase 12 antibody
    • Mitogen activated protein kinase p38 gamma antibody
    • Mitogen-activated protein kinase 12 antibody
    • Mitogen-activated protein kinase p38 gamma antibody
    • MK12_HUMAN antibody
    • P38 GAMMA antibody
    • P38GAMMA antibody
    • PRKM12 antibody
    • SAPK 3 antibody
    • SAPK-3 antibody
    • SAPK3 antibody
    • Stress Activated Protein Kinase 3 antibody
    • Stress-activated protein kinase 3 antibody
    see all

Images

  • Anti-SAPK3 antibody (ab37932) at 1/100 dilution + mouse muscle tissue lysate

    Secondary
    HRP-anti-rabbit
    Developed using the ECL technique

    Predicted band size : 42 kDa
    Observed band size : 42 kDa

References

ab37932 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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